Take Exit 3 from Interstate 95. At the exit stoplight, turn east on Highway 40. Follow the signs traveling east into Historic St. Marys. Highway 40 East will also be named Osborne Street. Once you reach the historic district, turn right at the stop sign onto St. Marys Street. The NPS Visitor Center is the blue building and the Ferry dock are both located on the left.
For GPS users, try the following address: 113 St. Marys Street St. Marys, GA 31558. This is our visitor center address and will get you to the right location. If you simply put in Cumberland Island National Seashore, your GPS unit will likely take you to Crooked River State Park as this is the closest boat ramp to the Seashore.